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Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation[...]
Discussion
Genes previously associated with asthma and hypertension.
The overlap between genes associated with asthma and hypertension independently.
Network analysis of shared genes reveals six modules.
Figure 1 Identification and characterization of gene modules associated with asthma and hypertension.
Table 1 Genes potentially involved in the pathophysiology of asthma and hypertension, according to literature published before 2018.
Analysis of evidence types supporting gene-disease associations.
Adverse drug reactions may mediate comorbidity of asthma and hypertension.
Discussion
Figure 2 Evidence sources supporting gene associations with asthma and hypertension.
Methods
Monogenic associations via hereditary asthma and hypertension.
Coding GWAS variants.
Regulation.
Table 2 Genes overrepresented among targets of drugs influencing asthma and hypertension.
Differentially expressed genes.
Drugs and drug targets.
Figure 3 Relationships between genes and drugs indicated and contraindicated in asthma and hypertension.
Statistical tests.
Table 3 Characteristics of eQTL datasets.
Acknowledgements
Aufsatz in einer Zeitschrift
Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects
Entstehung
2019
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