Zolotareva, Olga; Saik, Olga V.; Königs, Cassandra; Bragina, Elena Yu.; Goncharova, Irina A.; Freidin, Maxim B.; Dosenko, Victor E.; Ivanisenko, Vladimir A.; Hofestädt, Ralf: Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects. In: Scientific Reports. Jg.9 H. 1. 2019
Inhalt
- Genes previously associated with asthma and hypertension.
- The overlap between genes associated with asthma and hypertension independently.
- Network analysis of shared genes reveals six modules.
- Figure 1 Identification and characterization of gene modules associated with asthma and hypertension.
- Table 1 Genes potentially involved in the pathophysiology of asthma and hypertension, according to literature published before 2018.
- Analysis of evidence types supporting gene-disease associations.
- Adverse drug reactions may mediate comorbidity of asthma and hypertension.
- Discussion
- Figure 2 Evidence sources supporting gene associations with asthma and hypertension.
- Methods
- Table 2 Genes overrepresented among targets of drugs influencing asthma and hypertension.
- Figure 3 Relationships between genes and drugs indicated and contraindicated in asthma and hypertension.
- Table 3 Characteristics of eQTL datasets.
- Acknowledgements