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Quantitative Phase Imaging Using Digital Holographic Microscopy Reliably Assesses[...]
Acknowledgements
Study population.
Assessment of the optical path length delay and the refractive index of non-stenotic and stenotic intestinal tissue using d ...
Figure 1 Experimental set-up.
Table 1 Characteristics of patients with Crohn’s disease associated intestinal strictures undergoing surgical resection of the stricture.
Evaluation of fibrotic alterations within tissue samples by immunofluorescence.
Correlation between the refractive index and intestinal fibrosis.
Figure 2 Determination of the refractive index of stenotic and non-stenotic intestinal tissue of Crohn’s disease patients using digital holographic microscopy (DHM).
Table 2 Significantly prolonged average optical path length delay Δϕ and refractive index (RI) in stenotic compared to non-stenotic intestinal tissue of Crohn’s disease patients (surgical resection specimen n = 30 number of patients = 15).
Tissue stiffness is increased in fibrotic strictures.
Figure 3 Immunofluorescence studies of non-stenotic and stenotic intestinal tissue of Crohn’s disease patients.
Discussion
Figure 4 Significant correlation between the refractive index (RI) determined by digital holography microscopy (DHM) and the immunofluroescence-intensity of fibrosis markers.
Figure 5 Tissue stiffness of stenotic intestinal tissue was significantly elevated compared to non-stenotic intestinal tissue of Crohn’s disease patients.
Methods
Study design and inclusion criteria.
Histological evaluation.
Quantitative phase imaging with digital holographic microscopy.
Determination of the refractive index using digital holographic microscopy.
Evaluation of density changes of intestinal tissue of CD patients by digital holographic microscopy.
Immunofluorescence studies for the assessment of fibrosis in intestinal tissue.
Assessment of the tissue stiffness of intestinal tissue.
Statistical analysis.
Acknowledgements
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Quantitative Phase Imaging Using Digital Holographic Microscopy Reliably Assesses Morphology and Reflects Elastic Properties of Fibrotic Intestinal Tissue
Entstehung
18.12.2019
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