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A Matter of Choice: Inhibition of c-Rel Shifts Neuronal to Oligodendroglial Fate[...]
Materials and Methods
Quantitative Polymerase Chain Reaction (qPCR)
Materials and Methods
Isolation and Cultivation of Human NCSCs
Neuronal Differentiation of Human NCSCs to Glutamatergic Neurons
Pentoxifylline Treatment
Cerebellar Slice Culture, Demyelination and Cell Transplantation
Immunocytochemistry
Quantitative Polymerase Chain Reaction (qPCR)
Image Analyses and Quantification
Statistical Analyses
Results
NF-B-c-REL during Early Stages of Glutamatergic Differentiation in NCSC-Derived NSCs
NF-B-c-REL is Crucial for Cell Survival during Glutamatergic Differentiation of Adult Human Stem Cells
c-REL Inhibition by Pentoxifylline Induces a Shift into the Oligodendrocyte Fate
Transplanted PTXF-Treated Predifferentiated NSCs into Demyelinated Mouse Organotypic Cerebellar Slices Integrate and Differentiate into Myelinating Oligodendrocytes
Discussion
References
Aufsatz in einer Zeitschrift
A Matter of Choice: Inhibition of c-Rel Shifts Neuronal to Oligodendroglial Fate in Human Stem Cells
Entstehung
2020
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