Müller, Franziska Maria; Holert, Johannes; Yücel, Onur; Philipp, Bodo: Degradation of Bile Acids by Soil and Water Bacteria
Inhalt
- Bacterial Bile Acid Degradation
- Diversity of Bile Acid-Degrading Bacteria
- General Aspects of Metabolic Bile Acid Degradation Pathways
- Uptake of Bile Acids
- Oxidative Reactions at the A-Ring (Phase 1)
- Side-Chain Degradation (Phase 2)
- Cleavage of Conjugated Bile Acids
- Coenzyme-A Activation
- ,-Dehydrogenation
- Hydroxylation of the Double Bond
- Release of Acetyl-CoA and Formation of C3-Carboxylic Side Chains
- Release of Propionyl-CoA and Formation of Androstadienediones (ADDs)
- Aerobic Cleavage of the Steroid Skeleton via the 9,10-Seco Pathway (Phase 3a)
- Anaerobic Cleavage of the Steroid Skeleton via the 2,3-Seco Pathway (Phase 3b)
- C/D-Ring Degradation (Phase 4)
- Fate of Hydroxy Groups on the Steroid Nucleus
- Resistance Mechanisms against the Toxic Effects of Bile Acids
- Regulation of Bile-Acid Degradation
- Potential Ecological Effects of Bacterial Bile-Acid Degradation
- Applied Aspects of Bacterial Bile-Acid Degradation
- Conclusions and Future Perspectives
- References