Stölting, Miriam; Geyer, Christiane; Helfen, Anne; Hahnenkamp, Anke; Usai, Marco V.; Wardelmann, Eva; Kuhlmann, Michael Theodor; Wildgruber, Moritz; Höltke, Carsten: Monitoring Endothelin-A Receptor Expression during the Progression of Atherosclerosis
Inhalt
- Experimental Section
- Chemistry and Reagents
- Histology and Immunofluorescence of Cryosections
- Histology and Immunohistochemistry (IHC)
- Patient Recruitment and Tissue Extraction
- Mice
- Imaging
- Tissue Preparation and RNA Isolation
- qPCR
- Statistical Analysis
- Results
- ApoE-/- Mice Show Enhanced ETAR Expression after High-Fat Diet
- Molecular Imaging Shows Increased Probe Uptake in Aortic Lesions of ApoE-/- Mice
- Expression of ETAR Is Reduced in Advanced Human Endarterectomy Specimens
- Reduced ETAR Expression in Human Atherosclerotic Plaques Can Be Depicted by FRI
- Discussion
- Conclusions
- References