Robledo, Sara M.; Murillo, Javier; Arbeláez, Natalia; Montoya, Andrés; Ospina, Victoria; Jürgens, Franziska M.; Vélez, Iván D.; Schmidt, Thomas J.: Therapeutic Efficacy of 'Arnica' in Hamsters with Cutaneous Leishmaniasis Caused by 'Leishmania braziliensis' and 'L. tropica'
Inhalt
- Results and Discussion
- In Vitro Cytotoxicity of AT and STLs against Human Macrophages, Skin Fibroblasts, and Liver Cells
- In Vitro Antileishmanial Activity
- Response of Hamsters with CL Caused by L. braziliensis and L. tropica to Treatment with Arnica Tincture and other Formulations
- Skin Penetration of STLs from AT and Semisolid Preparations
- Residual Parasite Load in Cured Animals’ Skin
- Possible Influence of AT on Wound Healing
- Materials and Methods
- Arnica Tincture and STLs
- Arnica Formulations
- Human Cells and Culture
- Parasites and Culture
- Animals and Housing
- In Vitro Cytotoxicity Assay
- Infection of Human Macrophages (U937) with L. braziliensis and L. tropica and Exposure to Arnica Tincture and STLs
- Intradermal Infection of Golden Hamsters with L. braziliensis and L. tropica and Therapeutic Schemes
- Estimation of Parasite Load in Healed Skin Specimens by RT-qPCR
- Expression of Growth Factors Associated with Wound Healing
- In Vitro Wound Healing Assay (Scratch Test)
- Skin Penetration Experiments with Golden Hamster Skin in Franz Diffusion Cell
- Statistical Analysis
- Conclusions
- References