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Szabó, Lara U.; Kaiser, Marcel; Mäser, Pascal ; Schmidt, Thomas J.: Identification of Antiprotozoal Compounds from Buxus sempervirens L. by PLS-Prediction
Content
Results and Discussion
Antiprotozoal Activity of Crude Extract and Fractions from B. sempervirens L.
PLS Modeling
PLS-Prediction of Antiplasmodial Compounds from B. sempervirens L.
Identification of the Antiplasmodial Compounds Highlighted by the PLS Model
PLS-Prediction of Antitrypanosomal Compounds from B. sempervirens L.
Identification of the Antitrypanosomal Compounds Highlighted by the PLS Model
PLS-Prediction of Cytotoxic Compounds from B. sempervirens L.
Materials and Methods
Plant Material
Extraction and Fractionation of B. sempervirens L. Leaves
UHPLC/+ESI-QqTOF-Mass Spectrometry
Pretreatment of LC/MS Data
PLS Modeling
In Vitro Bioassays
Conclusions
References