Freundt, Johanna K.; Frommeyer, Gerrit; Spieker, Georg Tilmann; Wötzel, Fabian; Schulze Grotthoff, Jochen; Stypmann, Jörg; Hempel, Georg; Schäfers, Michael; Jacobs, Andreas H.; Eckardt, Lars; Lange, Philipp Sebastian: Histone deacetylase inhibition by Entinostat for the prevention of electrical and structural remodeling in heart failure
Inhalt
- Methods
- Animals
- Induction of heart failure and administration of Entinostat
- Langendorff system
- Immunohistochemistry
- Preparations of protein lysates and Western blot analyses
- Statistical analysis
- Results
- Alteration in failing hearts
- Electrophysiological effect of Entinostat in sham and failing hearts
- Effect of Entinostat on ion channel expression in sham and failing hearts
- Effects of Entinostat on fibrosis in vivo
- Discussion
- Additional files
- Abbreviations
- Acknowledgments
- Funding
- Availability of data and materials
- Authors’ contributions
- Ethics approval and consent to participate
- Consent for publication
- Competing interests
- Publisher’s Note
- Author details
- References