Freundt, Johanna K. ; Frommeyer, Gerrit ; Spieker, Georg Tilmann ; Wötzel, Fabian ; Schulze Grotthoff, Jochen; Stypmann, Jörg ; Hempel, Georg; Schäfers, Michael ; Jacobs, Andreas H. ; Eckardt, Lars ; Lange, Philipp Sebastian: Histone deacetylase inhibition by Entinostat for the prevention of electrical and structural remodeling in heart failure
Inhalt
- Methods
- Animals
- Induction of heart failure and administration of Entinostat
- Langendorff system
- Immunohistochemistry
- Preparations of protein lysates and Western blot analyses
- Statistical analysis
- Results
- Alteration in failing hearts
- Electrophysiological effect of Entinostat in sham and failing hearts
- Effect of Entinostat on ion channel expression in sham and failing hearts
- Effects of Entinostat on fibrosis in vivo
- Discussion
- Additional files
- Abbreviations
- Acknowledgments
- Funding
- Availability of data and materials
- Authors’ contributions
- Ethics approval and consent to participate
- Consent for publication
- Competing interests
- Publisher’s Note
- Author details
- References