Salo, Katharina I.; Scharfen, Jana ; Wilden, Isabelle D.; Schubotz, Ricarda Ines ; Holling, Heinz: Confining the Concept of Vascular Depression to Late-Onset Depression: A Meta-Analysis of MRI-Defined Hyperintensity Burden in Major Depressive Disorder [...]
Content
- Rationale
- Hyperintense Lesions
- The Vascular Depression Hypothesis
- Objectives
- Review of the Meta-Analytic State of Research
- Hypotheses
- Method
- Search Strategy
- Inclusion and Exclusion Criteria
- Coding Scheme
- Effect Size Measure
- Statistical Analyses
- Results
- Discussion
- Summary of Main Findings
- Linking Hyperintensities and Depression
- Hyperintensities Displaying Disruption in White Matter Tracts
- Hyperintensity-Related Correlates on Molecular Level
- Hyperintensity Burden in MDD vs. BD
- Theoretical Implications: Confining the Vascular Depression Hypothesis
- Neuropathological Correlates of Late-Onset Depression
- Limitations
- Future Research
- Clinical Implications
- Final Conclusions
- Author Contributions
- Supplementary Material
- References