Weiss, Daniel; Koopmann, Mario; Basel, Türker; Rudack, Claudia: Cyclin A1 shows age-related expression in benign tonsils, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently [...]
Inhalt
- Results
- Immunohistochemical expression of Cyclin A1 in HNSCC and controls
- Prevalence of HPV16 DNA, overexpression of p16 or p53, and p53 mutation in HNSCC and controls
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- Correlation of Cyclin A1 expression with clinicopathological parameters in controls
- Correlation of Cyclin A1 expression with clinicopathological parameters in HNSCC
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- Discussion
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- Conclusions
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- Methods
- Patients and controls
- Quantitative HPV16 E6/E7 &b_k;Real-&e_k;&b_k;Time&e_k; PCR and HPV &b_k;in-&e_k;&b_k;situ&e_k; hybridization
- Quantitation of HPV16 E6 and E7 DNA using &b_k;Real-&e_k;&b_k;Time&e_k; PCR
- Immunohistochemical analysis of Cyclin A1, CDKN2A/p16 and p53
- Methylation specific Polymerase Chain Reaction
- Mutation analysis of p53
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- Competing interests
- Acknowledgements
- Authors’ contributions
- References
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