Wittek, Andreas: Mechanical and pathophysiological in vivo characterization of the individual aortic wall based on 4D ultrasound imaging. 2020
Inhalt
- Title page
- Preface
- Summary
- Zusammenfassung
- Contents
- Nomenclature
- 1 Introduction
- 1.1 Motivation by the abdominal aortic aneurysmrupture risk estimation
- 1.2 Organization of the thesis
- 1.3 The heart and the physiological function of thearteries’ elastic properties
- 1.4 Microstructural elements and compositionof the aortic wall
- 1.5 Mechanical properties of the aortic wall
- 1.6 Axial prestretch and residual stresses
- 1.7 Degenerative changes of the aorta‘s elastic properties with age and pathology
- 2 Continuum mechanical framework
- 3 A method for non-invasive fullfield strain measurement
- 3.1 Ultrasound measurement of aortic wall deformation
- 3.2 Clinical data acquisition and post-processing
- 3.3 Deformation metrics based on customized 4D ultrasound wall motion data
- 3.4 Effects of increased spatial resolution on in vivo strain measurement
- 3.5 Characteristic size of aortic wall motion in vivoThe
- 4 In vitro validation of full-field wall motion measurement
- 4.1 Introduction
- 4.2 Methods of the in vitro validation study
- 4.3 Results of the validation study
- 4.4 Discussion of the validation results
- 4.5 Limitations of the validation study
- 5 Comparative Analysis of ascending and abdominal aortic wall motion
- 5.1 Introduction
- 5.2 Study collective and in vivo data acquisition
- 5.3 Statistics
- 5.4 Multiaxial deformation of the ascending and the abdominal aorta
- 5.5 Relations between deformation patterns and physiological function
- 6 Locally varying elastic behavior of human aortae in vivo
- 6.1 In vivo measures of aortic elasticity in thephysiological range
- 6.2 The local distensibility coefficient
- 6.3 Indices for the characterization of the spatial distribution of the local elastic behavior
- 6.4 Distributions of local elasticity in young, aged and aneurysmal aortic walls
- 6.5 Discussion and limitations
- 7 Identification of the orthotropic and hyperelastic constitutive behaviorof aortic walls in vivo
- 7.1 Introduction
- 7.2 Assumptions for the patient-specific modeling
- 7.3 Theoretical basis for constitutive parameter identification in vivo
- 7.4 Constitutive equation
- 7.5 Non-invasive in vivo data
- 7.6 Model-based estimation of systolic in-plane strains
- 7.7 Constitutive parameter identification strategy
- 7.8 Numerical verification experiment
- 7.9 Results of the verification experiment
- 7.10 Individual constitutive behavior identified based on in vivo data
- 7.11 Discussion and conclusions
- 8 Summary and outlook
- 9 References
- Appendix