Rösner, Janin: Identification and analysis of transporters involved in the elimination of insecticidal compounds from the red flour beetle, Tribolium castaneum. 2021
Inhalt
- TABLE OF CONTENTS
- SUMMARY
- ZUSAMMENFASSUNG
- INTRODUCTION
- 1.1 ABOUT INSECTS, PESTS AND COLEOPTERA
- 1.2 TRIBOLIUM CASTANEUM AS MODEL ORGANISM FOR INVESTIGATING MECHANISMS OF INSECTICIDE RESISTANCE
- 1.3 INSECTICIDES, RESISTANCES AND THEIR DEVELOPMENT
- 1.4 ATP-BINDING CASSETTE TRANSPORTER
- 1.5 ORGANIC ANION TRANSPORTING POLYPEPTIDES
- 1.6 OBJECTIVE OF THE WORK
- MATERIAL AND METHODS
- RESULTS
- 3.1 INTRODUCTION
- 3.2 ANALYSES OF INSECTICIDAL EFFECTS
- 3.3 COMPETITIVE FLUORESENCE-BASED ELIMINATION ASSAY
- 3.4 ATP-BINDING CASSETTE TRANSPORTERS
- 3.5 ORGANIC ANION TRANSPORTING POLYPETIDES
- DISCUSSION
- 4.1 INTRODUCTION
- 4.2 ABC TRANSPORTERS AND THEIR ROLE IN INSECTICIDE ELIMINATION
- 4.3 THE DISCOVERY OF NOVEL RNAI PHENOTYPES FOR TCABC GENES
- 4.4 OATPS AND THEIR ROLE IN INSECTICIDE ELIMINATION
- 4.5 THE ROLE OF TCOATP4-C1 AS A PUTATIVE ECYDSONE IMPORTER
- 4.6 THE COMBINED ACTION OF IMPORTERS AND EXPORTERS IN INSECTICIDE ELIMINATION
- 4.7 INHIBITORS CAN BE USED TO ENHANCE THE SENSITIVITY TO INSECTICIDES
- 4.8 UPREGULATION OF GENE EXPRESSION IN RESPONSE TO INSECTICIDE TREATMENT DOES NOT NECESSARILY INDICATE THEIR CONTRIBUTION TO RESISTANCE
- 4.9 RNAI AS A SPECIES-SPECIFIC PEST MANAGEMENT STRATEGY
- OUTLOOK
- APPENDIX
- 7.1 ABBREVATIONS
- 7.2 IRAC MODE OF ACTION CLASSIFICATION SCHEME
- 7.3 KIT SYSTEMS
- 7.4 GENES
- 7.5 PLASMID
- 7.6 SUPPLEMENTARY DATA
- REFERENCES
- PUBLICATIONS