TY  - THES
AB  - In preparation for a structure-activity relationship (SAR) study, 11 different analogues of the cytostatic compound cryptophycin-1 were synthesised. Therefore, modified unit C building blocks comprising [alpha]-functionalised [beta]-amino acids were incorporated into the cryptophycin framework. These so-called [beta]2-amino acids were prepared by using conventional Evans' auxiliary chemistry. Furthermore, a novel chiral and cyclic N,N-acetal of benzaldehyde was developed, which may function as a universal [beta]2-amino acid precursor. Finally, "clicktophycin-52" was synthesised, which represents the first cryptophycin triazole analogue.
DA  - 2009
KW  - Cryptophycine , Aminosäuren (beta-) , Totalsynthese , Stereoselektive Synthese , Naturstoffe , Krebsmedikament , Medizinische Chemie , Peptidsynthese , Stereoselective synthesis , Natural products , Anticancer agent , Medicinal chemistry , Peptide synthesis
LA  - ger
PY  - 2009
TI  - [beta]2-Aminosäuren als Bausteine funktionalisierter Cryptophycin-Analoga
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:361-16733
Y2  - 2024-11-14T06:45:12
ER  -