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EGFR-Binding Peptides: From Computational Design towards Tumor-Targeting of Adeno-Associated[...]
Materials and Methods
Peptide Cleavage
Results
Computational Design of -Hairpin Peptides Competitively Inhibiting Dimerization of EGFR
Synthesis and Cyclization Of Peptides
Biophysical Characterization of Peptides
Cyclic Peptides Show Binding to Cells Expressing EGFR at High and Low Levels
Cyclic Peptide Pep1osy Shows Inhibitory Properties in Wound Healing Assays
Peptides Grafted on the Recombinant Adeno-Associated Virus 2 Capsid
Insertion of Designed EGFR-Targeting Peptides Changes the Tropism of rAAV2 towards EGFR Overexpressing Cells
rAAV2 587 Pep1jhf Demonstrates Efficacy in Egg Xenografts
Discussion
Materials and Methods
Structural Modeling
General Procedure
Peptide Synthesis
N-Terminal Fluorescein Labeling
Peptide Cleavage
Cyclization of Peptides
Cell Culture
Wound Healing Assay
Confocal Fluorescence Microscopy
Circular Dichroism Spectrometry
Fluorescence Polarization
Viral Particle Production
Purification of Viral Particles
SDS-PAGE and Western Blot Analysis
Determination of Genomic Titers
Transduction Assay
Chorioallantoic Membrane (CAM) Assay
References
Aufsatz in einer Zeitschrift
EGFR-Binding Peptides: From Computational Design towards Tumor-Targeting of Adeno-Associated Virus Capsids
Entstehung
2020
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