Pierrel, Fabien; Burgardt, Arthur; Lee, Jin-Ho; Pelosi, Ludovic; Wendisch, Volker F.: Recent Advances in the Metabolic Pathways and Microbial Production of Coenzyme Q. In: World Journal of Microbiology and Biotechnology. Jg.38. 2022
Inhalt
- Synthesis of the precursors of the head group of CoQ
- Synthesis of the polyprenyl side chain
- Functionalization of the head group
- Decarboxylation
- Hydroxylation reactions
- Methylation reactions
- Supramolecular organization of the enzymes that modify the head group
- Regulation of CoQ biosynthesis
- Strategies to improve ubiquinone-related production in microorganisms
- Improving precursor supply of benzoquinone ring for ubiquinone production
- Improving precursor supply of polyprenyl diphosphate for ubiquinone production
- CoQ10 production by bacteria natively synthesizing CoQ10
- Metabolic engineering strategies for the overproduction of CoQ10
- Metabolic engineering of E. coli to produce CoQ10
- Genetic engineering of bacteria that natively produce CoQ10
- CoQ10 production in bacteria that do not natively produce CoQ
- Conclusions and future perspectives
- References