Schmitz, Julian; Höving, Anna L.; Schmidt, Kazuko E.; Greiner, Johannes; Knabbe, Cornelius; Kaltschmidt, Barbara; Grünberger, Alexander; Kaltschmidt, Christian: Human Blood Serum Induces p38-MAPK- and Hsp27-Dependent Migration Dynamics of Adult Human Cardiac Stem Cells: Single-Cell Analysis via a Microfluidic-Based [...]. In: Biology. Jg.10 H. 8. 2021
Inhalt
- Introduction
- Materials and Methods
- Isolation and Cultivation of Human Cardiac Stem Cells
- Microfluidics
- Immunocytochemistry
- Data Analysis
- Results
- Successful Cultivation of Human Cardiac Stem Cells in a Microfluidic Cultivation Device
- Migrating hCSCs Exhibit Diverse Morphologies and Migration Patterns
- Human Blood Serum Enhances the Migration Distance and Speed of hCSCs
- Inhibition of p38-MAPK Leads to Decreased Migration of Blood-Serum Stimulated hCSCs
- Serum-Induced Migration of hCSCs Is Regulated via p38-MAPK and Hsp27-Phosphorylation
- Discussion
- Conclusions
- References