Windmöller, Beatrice Ariane; Beshay, Morris; Helweg, Laureen P.; Flottmann, Clara; Beermann, Miriam; Förster, Christine; Wilkens, Ludwig; Greiner, Johannes; Kaltschmidt, Christian; Kaltschmidt, Barbara: Novel Primary Human Cancer Stem-Like Cell Populations from Non-Small Cell Lung Cancer: Inhibition of Cell Survival by Targeting NF-κB and MYC Signalin [...]. In: Cells. Jg.10 H. 5. 2021
Inhalt
- Materials and Methods
- Lung Cancer Stem Cell-like Cell Population Establishment and Cell Culture
- Immunocytochemistry
- Western Blot
- Senescence Assay
- Quantitaive Polymerase Chain Reaction
- Inhibitor Treatments
- Statistical Analysis
- Results
- Squamous Cell Carcinoma- and Adenocarcinoma-Derived Cells Depicted Stemness-like Phenotype
- Tumor Necrosis Factor- Stimulation Activated NF-B RelA in Squamous Cell Carcinoma- and Adenocarcinoma-Derived Lung Cancer Stem Cell-like Cells
- Inhibition of MYC and NMYC in Squamous Cell Carcinoma- and Adenocarcinoma-Derived Lung Cancer Stem Cell-like Cells Significantly Impaired Cell Survival
- Inhibition of NF-B Signaling Decreased Survival of Squamous Cell Carcinoma- and Adenocarcinoma-Derived Lung Cancer Stem Cell-like Cells
- Discussion
- References