Lüningschrör, Patrick; Slotta, Carsten; Heimann, Peter; Briese, Michael; Weikert, Ulrich; Massih, Bita; Appenzeller, Silke; Sendtner, Michael; Kaltschmidt, Christian; Kaltschmidt, Barbara: Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral [...]. In: Frontiers in Cellular Neuroscience. Jg.14. 2020
Inhalt
- Statistical Analysis
- Animals
- Light and Electron Microscopy
- Morphometric Analysis and Determination of g-Ratio
- Immunohistochemical Stainings
- RNA Extraction and qPCR
- Lentivirus Production
- Primary Schwann Cell Culture
- RNAseq
- Cultivation of Sciatic Nerve Segments
- Quantification of Autophagosomes and Autolysosomes
- RESULTS
- Plekhg5-Deficiency Disrupts the Integrity of Schwann Cell–Axon Units
- Impaired Formation of Autophagosomes in Plekhg5-Deficient Schwann Cells
- Reduced Recruitment of T-Lymphocytes Within the Sciatic Nerve
- DISCUSSION
- DATA AVAILABILITY STATEMENT
- ETHICS STATEMENT
- AUTHOR CONTRIBUTIONS
- FUNDING
- ACKNOWLEDGMENTS
- SUPPLEMENTARY MATERIAL
- REFERENCES