Serpeloni, Fernanda; Radtke, Karl M.; Hecker, Tobias; Sill, Johanna; Vukojevic, Vanja; Assis, Simone G. de; Schauer, Maggie; Elbert, Thomas; Nätt, Daniel: Does Prenatal Stress Shape Postnatal Resilience? – An Epigenome-Wide Study on Violence and Mental Health in Humans. In: Frontiers in Genetics. Jg.10. 2019, S. 269 ff.
Inhalt
- Materials and Methods
- Participants
- Pre- and Postnatal Stress
- Stress-Related Disorders
- Generating DNA Methylation Data
- Preprocessing and Quality Control of DNA Methylation Data
- Genome-Wide Differential DNA Methylation Analysis
- Stress-Induced Methylome Switching and Retrotransposon Analysis
- Cell Type and Genetic Ancestry
- Statistical Models
- Analysis of Contrast Datasets
- Ethics Statement
- Results
- Psychiatric Burden in Children Exposed to Prenatal IPV
- Prenatal IPV Affects Genes Relevant for Stress and Psychiatric Disorder
- Stress Tolerance and Methylome Switching in São Gonçalo Children
- Children Exposed to Both Prenatal IPV and Postnatal Violence Share aUnique Relationship
- Discussion
- Conclusion
- Author Contributions
- Funding
- Acknowledgments
- Supplementary Material
- References