{"viewingHint":"paged","service":[{"profile":"http://iiif.io/api/search/1/search","@context":"http://iiif.io/api/search/1/context.json","@id":"https://noah.nrw/i3f/manifest/6824721/search","label":"Search within this manifest"}],"license":"https://creativecommons.org/licenses/by/4.0/deed.de","structures":[{"ranges":["https://noah.nrw/i3f/v20/6824721/range/6865071","https://noah.nrw/i3f/v20/6824721/range/6865084","https://noah.nrw/i3f/v20/6824721/range/6865092","https://noah.nrw/i3f/v20/6824721/range/6865094","https://noah.nrw/i3f/v20/6824721/range/6865096"],"viewingHint":"top","@id":"https://noah.nrw/i3f/v20/6824721/range/6824721","@type":"sc:Range","label":"Table of Contents"},{"canvases":["https://noah.nrw/i3f/v20/6824721/canvas/6865073","https://noah.nrw/i3f/v20/6824721/canvas/6865075","https://noah.nrw/i3f/v20/6824721/canvas/6865080"],"ranges":["https://noah.nrw/i3f/v20/6824721/range/6865072","https://noah.nrw/i3f/v20/6824721/range/6865074","https://noah.nrw/i3f/v20/6824721/range/6865076","https://noah.nrw/i3f/v20/6824721/range/6865077","https://noah.nrw/i3f/v20/6824721/range/6865078","https://noah.nrw/i3f/v20/6824721/range/6865079","https://noah.nrw/i3f/v20/6824721/range/6865081","https://noah.nrw/i3f/v20/6824721/range/6865082","https://noah.nrw/i3f/v20/6824721/range/6865083"],"@id":"https://noah.nrw/i3f/v20/6824721/range/6865071","@type":"sc:Range","label":"Materials and Methods "},{"canvases":["https://noah.nrw/i3f/v20/6824721/canvas/6865073"],"@id":"https://noah.nrw/i3f/v20/6824721/range/6865072","@type":"sc:Range","label":"Cell Culture "},{"canvases":["https://noah.nrw/i3f/v20/6824721/canvas/6865075"],"@id":"https://noah.nrw/i3f/v20/6824721/range/6865074","@type":"sc:Range","label":"Seahorse Extracellular Flux Analysis "},{"canvases":["https://noah.nrw/i3f/v20/6824721/canvas/6865080"],"@id":"https://noah.nrw/i3f/v20/6824721/range/6865079","@type":"sc:Range","label":"Metformin Treatment "},{"canvases":["https://noah.nrw/i3f/v20/6824721/canvas/6865087","https://noah.nrw/i3f/v20/6824721/canvas/6865088","https://noah.nrw/i3f/v20/6824721/canvas/6865090","https://noah.nrw/i3f/v20/6824721/canvas/6865091"],"ranges":["https://noah.nrw/i3f/v20/6824721/range/6865085","https://noah.nrw/i3f/v20/6824721/range/6865086","https://noah.nrw/i3f/v20/6824721/range/6865089"],"@id":"https://noah.nrw/i3f/v20/6824721/range/6865084","@type":"sc:Range","label":"Results "},{"canvases":["https://noah.nrw/i3f/v20/6824721/canvas/6865087","https://noah.nrw/i3f/v20/6824721/canvas/6865088"],"@id":"https://noah.nrw/i3f/v20/6824721/range/6865086","@type":"sc:Range","label":"MLL/AF9 Gene Expression Is Associated with Increased Mitochondrial Respiration "},{"canvases":["https://noah.nrw/i3f/v20/6824721/canvas/6865090","https://noah.nrw/i3f/v20/6824721/canvas/6865091"],"@id":"https://noah.nrw/i3f/v20/6824721/range/6865089","@type":"sc:Range","label":"MLL/AF9 AML Cells Are More Sensitive to Metformin Treatment "},{"canvases":["https://noah.nrw/i3f/v20/6824721/canvas/6865093"],"@id":"https://noah.nrw/i3f/v20/6824721/range/6865092","@type":"sc:Range","label":"Discussion "},{"canvases":["https://noah.nrw/i3f/v20/6824721/canvas/6865095"],"@id":"https://noah.nrw/i3f/v20/6824721/range/6865094","@type":"sc:Range","label":"Conclusions "},{"canvases":["https://noah.nrw/i3f/v20/6824721/canvas/6865097","https://noah.nrw/i3f/v20/6824721/canvas/6865098"],"@id":"https://noah.nrw/i3f/v20/6824721/range/6865096","@type":"sc:Range","label":"References"}],"sequences":[{"canvases":[{"height":2339,"width":1654,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/6865070"},"format":"image/jpeg","height":1414,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/6865070","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/6824721/canvas/6865070","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/6824721/annotation/6865070","@type":"oa:Annotation"}],"label":"[1]","@id":"https://noah.nrw/i3f/v20/6824721/canvas/6865070","@type":"sc:Canvas"},{"height":2339,"width":1654,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/6865073"},"format":"image/jpeg","height":1414,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/6865073","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/6824721/canvas/6865073","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/6824721/annotation/6865073","@type":"oa:Annotation"}],"label":"[2]","@id":"https://noah.nrw/i3f/v20/6824721/canvas/6865073","@type":"sc:Canvas"},{"height":2339,"width":1654,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/6865075"},"format":"image/jpeg","height":1414,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/6865075","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/6824721/canvas/6865075","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/6824721/annotation/6865075","@type":"oa:Annotation"}],"label":"[3]","@id":"https://noah.nrw/i3f/v20/6824721/canvas/6865075","@type":"sc:Canvas"},{"height":2339,"width":1654,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/6865080"},"format":"image/jpeg","height":1414,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/6865080","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/6824721/canvas/6865080","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/6824721/annotation/6865080","@type":"oa:Annotation"}],"label":"[4]","@id":"https://noah.nrw/i3f/v20/6824721/canvas/6865080","@type":"sc:Canvas"},{"height":2339,"width":1654,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/6865087"},"format":"image/jpeg","height":1414,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/6865087","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/6824721/canvas/6865087","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/6824721/annotation/6865087","@type":"oa:Annotation"}],"label":"[5]","@id":"https://noah.nrw/i3f/v20/6824721/canvas/6865087","@type":"sc:Canvas"},{"height":2339,"width":1654,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/6865088"},"format":"image/jpeg","height":1414,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/6865088","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/6824721/canvas/6865088","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/6824721/annotation/6865088","@type":"oa:Annotation"}],"label":"[6]","@id":"https://noah.nrw/i3f/v20/6824721/canvas/6865088","@type":"sc:Canvas"},{"height":2339,"width":1654,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/6865090"},"format":"image/jpeg","height":1414,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/6865090","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/6824721/canvas/6865090","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/6824721/annotation/6865090","@type":"oa:Annotation"}],"label":"[7]","@id":"https://noah.nrw/i3f/v20/6824721/canvas/6865090","@type":"sc:Canvas"},{"height":2339,"width":1654,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/6865091"},"format":"image/jpeg","height":1414,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/6865091","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/6824721/canvas/6865091","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/6824721/annotation/6865091","@type":"oa:Annotation"}],"label":"[8]","@id":"https://noah.nrw/i3f/v20/6824721/canvas/6865091","@type":"sc:Canvas"},{"height":2339,"width":1654,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/6865093"},"format":"image/jpeg","height":1414,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/6865093","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/6824721/canvas/6865093","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/6824721/annotation/6865093","@type":"oa:Annotation"}],"label":"[9]","@id":"https://noah.nrw/i3f/v20/6824721/canvas/6865093","@type":"sc:Canvas"},{"height":2339,"width":1654,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/6865095"},"format":"image/jpeg","height":1414,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/6865095","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/6824721/canvas/6865095","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/6824721/annotation/6865095","@type":"oa:Annotation"}],"label":"[10]","@id":"https://noah.nrw/i3f/v20/6824721/canvas/6865095","@type":"sc:Canvas"},{"height":2339,"width":1654,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/6865097"},"format":"image/jpeg","height":1414,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/6865097","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/6824721/canvas/6865097","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/6824721/annotation/6865097","@type":"oa:Annotation"}],"label":"[11]","@id":"https://noah.nrw/i3f/v20/6824721/canvas/6865097","@type":"sc:Canvas"},{"height":2339,"width":1654,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/6865098"},"format":"image/jpeg","height":1414,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/6865098","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/6824721/canvas/6865098","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/6824721/annotation/6865098","@type":"oa:Annotation"}],"label":"[12]","@id":"https://noah.nrw/i3f/v20/6824721/canvas/6865098","@type":"sc:Canvas"}],"viewingHint":"paged","startCanvas":"https://noah.nrw/i3f/v20/6824721/canvas/6865070","viewingDirection":"left-to-right","label":"Current Page Order","@context":"http://iiif.io/api/presentation/2/context.json","@id":"https://noah.nrw/i3f/v20/6824721/sequence/normal","@type":"sc:Sequence"}],"label":"High Metabolic Dependence on Oxidative Phosphorylation Drives Sensitivity to Metformin Treatment in MLL/AF9 Acute Myeloid Leukemia","thumbnail":{"width":304,"height":429,"@id":"https://noah.nrw/i3f/v21/6865070/full/304/0/default.jpg","@type":"dctypes:Image","format":"image/jpeg"},"logo":{"@id":"https://noah.nrw/domainresource/static/graphics/connectors/viewerLogo.gif","service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":""}},"@context":"http://iiif.io/api/presentation/2/context.json","metadata":[{"value":"High Metabolic Dependence on Oxidative Phosphorylation Drives Sensitivity to Metformin Treatment in MLL/AF9 Acute Myeloid Leukemia","label":"Titel"},{"value":"Liu, Longlong","label":"Verfasser"},{"value":"Patnana, Pradeep Kumar","label":"Verfasser"},{"value":"Xie, Xiaoqing","label":"Verfasser"},{"value":"Frank, Daria","label":"Verfasser"},{"value":"Nimmagadda, Subbaiah Chary","label":"Verfasser"},{"value":"Rosemann, Annegret","label":"Verfasser"},{"value":"Liebmann, Marie","label":"Verfasser"},{"value":"Klotz, Luisa Hildegard","label":"Verfasser"},{"value":"Opalka, Bertram","label":"Verfasser"},{"value":"Khandanpour, Cyrus","label":"Verfasser"},{"value":"19.1.2022","label":"Erschienen"},{"value":"Finanziert durch den Open-Access-Publikationsfonds der Westf\u00e4lischen Wilhelms-Universit\u00e4t M\u00fcnster (WWU M\u00fcnster).","label":"Anmerkung"},{"value":"Englisch","label":"Sprache"},{"value":"Cancers 14 (2022) 3, 486, 1-12","label":"Bibl. Referenz"},{"value":"Aufsatz in einer Zeitschrift","label":"Dokumenttyp"},{"value":"heterogeneity / OXPHOS / MLL/AF9 / metformin","label":"Schlagw\u00f6rter (EN)"},{"value":"urn:nbn:de:hbz:6-74069412000","label":"URN"},{"value":"10.17879/84069426952","label":"DOI"}],"@id":"https://noah.nrw/i3f/v20/6824721/manifest","@type":"sc:Manifest","seeAlso":{"format":"application/xml","@id":"https://noah.nrw/oai?verb=GetRecord&metadataPrefix=mets&identifier=6824721","label":"METS"}}