{"viewingHint":"paged","service":[{"profile":"http://iiif.io/api/search/1/search","@context":"http://iiif.io/api/search/1/context.json","@id":"https://noah.nrw/i3f/manifest/5104800/search","label":"Search within this manifest"}],"structures":[{"ranges":["https://noah.nrw/i3f/v20/5104800/range/5154608","https://noah.nrw/i3f/v20/5104800/range/5154610","https://noah.nrw/i3f/v20/5104800/range/5154623","https://noah.nrw/i3f/v20/5104800/range/5154628","https://noah.nrw/i3f/v20/5104800/range/5154634","https://noah.nrw/i3f/v20/5104800/range/5154635","https://noah.nrw/i3f/v20/5104800/range/5154636","https://noah.nrw/i3f/v20/5104800/range/5154637"],"viewingHint":"top","@id":"https://noah.nrw/i3f/v20/5104800/range/5104800","@type":"sc:Range","label":"Table of Contents"},{"canvases":["https://noah.nrw/i3f/v20/5104800/canvas/5154609"],"@id":"https://noah.nrw/i3f/v20/5104800/range/5154608","@type":"sc:Range","label":"Background"},{"canvases":["https://noah.nrw/i3f/v20/5104800/canvas/5154613","https://noah.nrw/i3f/v20/5104800/canvas/5154615","https://noah.nrw/i3f/v20/5104800/canvas/5154617","https://noah.nrw/i3f/v20/5104800/canvas/5154619","https://noah.nrw/i3f/v20/5104800/canvas/5154620","https://noah.nrw/i3f/v20/5104800/canvas/5154622"],"ranges":["https://noah.nrw/i3f/v20/5104800/range/5154611","https://noah.nrw/i3f/v20/5104800/range/5154612","https://noah.nrw/i3f/v20/5104800/range/5154614","https://noah.nrw/i3f/v20/5104800/range/5154616","https://noah.nrw/i3f/v20/5104800/range/5154618","https://noah.nrw/i3f/v20/5104800/range/5154621"],"@id":"https://noah.nrw/i3f/v20/5104800/range/5154610","@type":"sc:Range","label":"Results"},{"canvases":["https://noah.nrw/i3f/v20/5104800/canvas/5154613"],"@id":"https://noah.nrw/i3f/v20/5104800/range/5154612","@type":"sc:Range","label":"The mRNA levels of serine and histidine biosynthesis genes in rel-proficient C. glutamicum cultures treated with serine hydroxamate are induced and reach a maximum ten minutes after induction of the stringent response"},{"canvases":["https://noah.nrw/i3f/v20/5104800/canvas/5154615"],"@id":"https://noah.nrw/i3f/v20/5104800/range/5154614","@type":"sc:Range","label":"Comparison of transcriptional profiles of C. glutamicum rel-proficient and rel-deficient mutant strains before and after induction of the stringent response allowed to identify rel-dependent genes"},{"canvases":["https://noah.nrw/i3f/v20/5104800/canvas/5154617"],"@id":"https://noah.nrw/i3f/v20/5104800/range/5154616","@type":"sc:Range","label":"Class A genes are under (p)ppGpp mediated stringent control as they were found to be regulated SHX-treatment only in the rel-proficient RES167 strain but not in its rel- deficient derivative RES167Drel"},{"canvases":["https://noah.nrw/i3f/v20/5104800/canvas/5154619","https://noah.nrw/i3f/v20/5104800/canvas/5154620"],"@id":"https://noah.nrw/i3f/v20/5104800/range/5154618","@type":"sc:Range","label":"Class B genes are regulated Rel-independently and show a change in their expression in the rel-proficient strain and the rel-deficient mutant"},{"canvases":["https://noah.nrw/i3f/v20/5104800/canvas/5154622"],"@id":"https://noah.nrw/i3f/v20/5104800/range/5154621","@type":"sc:Range","label":"Class C genes belong to a variety of functional complexes and show differential regulation only in the rel-deficient mutant"},{"canvases":["https://noah.nrw/i3f/v20/5104800/canvas/5154624","https://noah.nrw/i3f/v20/5104800/canvas/5154625","https://noah.nrw/i3f/v20/5104800/canvas/5154626","https://noah.nrw/i3f/v20/5104800/canvas/5154627"],"@id":"https://noah.nrw/i3f/v20/5104800/range/5154623","@type":"sc:Range","label":"Discussion"},{"canvases":["https://noah.nrw/i3f/v20/5104800/canvas/5154630"],"ranges":["https://noah.nrw/i3f/v20/5104800/range/5154629","https://noah.nrw/i3f/v20/5104800/range/5154631","https://noah.nrw/i3f/v20/5104800/range/5154632","https://noah.nrw/i3f/v20/5104800/range/5154633"],"@id":"https://noah.nrw/i3f/v20/5104800/range/5154628","@type":"sc:Range","label":"Materials and methods"},{"canvases":["https://noah.nrw/i3f/v20/5104800/canvas/5154630"],"@id":"https://noah.nrw/i3f/v20/5104800/range/5154629","@type":"sc:Range","label":"Bacterial strains and growth conditions"},{"canvases":["https://noah.nrw/i3f/v20/5104800/canvas/5154638","https://noah.nrw/i3f/v20/5104800/canvas/5154639"],"@id":"https://noah.nrw/i3f/v20/5104800/range/5154637","@type":"sc:Range","label":"References"}],"sequences":[{"canvases":[{"height":2200,"width":1694,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/5154607"},"format":"image/jpeg","height":1298,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/5154607","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/5104800/canvas/5154607","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/5104800/annotation/5154607","@type":"oa:Annotation"}],"label":"[1]","@id":"https://noah.nrw/i3f/v20/5104800/canvas/5154607","@type":"sc:Canvas"},{"height":2200,"width":1694,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/5154609"},"format":"image/jpeg","height":1298,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/5154609","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/5104800/canvas/5154609","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/5104800/annotation/5154609","@type":"oa:Annotation"}],"label":"[2]","@id":"https://noah.nrw/i3f/v20/5104800/canvas/5154609","@type":"sc:Canvas"},{"height":2200,"width":1694,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/5154613"},"format":"image/jpeg","height":1298,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/5154613","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/5104800/canvas/5154613","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/5104800/annotation/5154613","@type":"oa:Annotation"}],"label":"[3]","@id":"https://noah.nrw/i3f/v20/5104800/canvas/5154613","@type":"sc:Canvas"},{"height":2200,"width":1694,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/5154615"},"format":"image/jpeg","height":1298,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/5154615","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/5104800/canvas/5154615","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/5104800/annotation/5154615","@type":"oa:Annotation"}],"label":"[4]","@id":"https://noah.nrw/i3f/v20/5104800/canvas/5154615","@type":"sc:Canvas"},{"height":2200,"width":1694,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/5154617"},"format":"image/jpeg","height":1298,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/5154617","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/5104800/canvas/5154617","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/5104800/annotation/5154617","@type":"oa:Annotation"}],"label":"[5]","@id":"https://noah.nrw/i3f/v20/5104800/canvas/5154617","@type":"sc:Canvas"},{"height":2200,"width":1694,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/5154619"},"format":"image/jpeg","height":1298,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/5154619","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/5104800/canvas/5154619","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/5104800/annotation/5154619","@type":"oa:Annotation"}],"label":"[6]","@id":"https://noah.nrw/i3f/v20/5104800/canvas/5154619","@type":"sc:Canvas"},{"height":2200,"width":1694,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/5154620"},"format":"image/jpeg","height":1298,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/5154620","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/5104800/canvas/5154620","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/5104800/annotation/5154620","@type":"oa:Annotation"}],"label":"[7]","@id":"https://noah.nrw/i3f/v20/5104800/canvas/5154620","@type":"sc:Canvas"},{"height":2200,"width":1694,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/5154622"},"format":"image/jpeg","height":1298,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/5154622","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/5104800/canvas/5154622","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/5104800/annotation/5154622","@type":"oa:Annotation"}],"label":"[8]","@id":"https://noah.nrw/i3f/v20/5104800/canvas/5154622","@type":"sc:Canvas"},{"height":2200,"width":1694,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/5154624"},"format":"image/jpeg","height":1298,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/5154624","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/5104800/canvas/5154624","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/5104800/annotation/5154624","@type":"oa:Annotation"}],"label":"[9]","@id":"https://noah.nrw/i3f/v20/5104800/canvas/5154624","@type":"sc:Canvas"},{"height":2200,"width":1694,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/5154625"},"format":"image/jpeg","height":1298,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/5154625","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/5104800/canvas/5154625","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/5104800/annotation/5154625","@type":"oa:Annotation"}],"label":"[10]","@id":"https://noah.nrw/i3f/v20/5104800/canvas/5154625","@type":"sc:Canvas"},{"height":2200,"width":1694,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/5154626"},"format":"image/jpeg","height":1298,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/5154626","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/5104800/canvas/5154626","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/5104800/annotation/5154626","@type":"oa:Annotation"}],"label":"[11]","@id":"https://noah.nrw/i3f/v20/5104800/canvas/5154626","@type":"sc:Canvas"},{"height":2200,"width":1694,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/5154627"},"format":"image/jpeg","height":1298,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/5154627","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/5104800/canvas/5154627","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/5104800/annotation/5154627","@type":"oa:Annotation"}],"label":"[12]","@id":"https://noah.nrw/i3f/v20/5104800/canvas/5154627","@type":"sc:Canvas"},{"height":2200,"width":1694,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/5154630"},"format":"image/jpeg","height":1298,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/5154630","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/5104800/canvas/5154630","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/5104800/annotation/5154630","@type":"oa:Annotation"}],"label":"[13]","@id":"https://noah.nrw/i3f/v20/5104800/canvas/5154630","@type":"sc:Canvas"},{"height":2200,"width":1694,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/5154638"},"format":"image/jpeg","height":1298,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/5154638","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/5104800/canvas/5154638","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/5104800/annotation/5154638","@type":"oa:Annotation"}],"label":"[14]","@id":"https://noah.nrw/i3f/v20/5104800/canvas/5154638","@type":"sc:Canvas"},{"height":2200,"width":1694,"images":[{"resource":{"service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":"https://noah.nrw/i3f/v20/5154639"},"format":"image/jpeg","height":1298,"width":1000,"@id":"https://noah.nrw/download/webcache/1000/5154639","@type":"dctypes:Image"},"on":"https://noah.nrw/i3f/v20/5104800/canvas/5154639","motivation":"sc:painting","@id":"https://noah.nrw/i3f/v20/5104800/annotation/5154639","@type":"oa:Annotation"}],"label":"[15]","@id":"https://noah.nrw/i3f/v20/5104800/canvas/5154639","@type":"sc:Canvas"}],"viewingHint":"paged","startCanvas":"https://noah.nrw/i3f/v20/5104800/canvas/5154607","viewingDirection":"left-to-right","label":"Current Page Order","@context":"http://iiif.io/api/presentation/2/context.json","@id":"https://noah.nrw/i3f/v20/5104800/sequence/normal","@type":"sc:Sequence"}],"label":"Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (p) ppGpp synthase","thumbnail":{"width":304,"height":394,"@id":"https://noah.nrw/i3f/v21/5154607/full/304/0/default.jpg","@type":"dctypes:Image","format":"image/jpeg"},"logo":{"@id":"https://noah.nrw/domainresource/static/graphics/connectors/viewerLogo.gif","service":{"profile":"http://iiif.io/api/image/2/level2.json","@context":"http://iiif.io/api/image/2/context.json","@id":""}},"@context":"http://iiif.io/api/presentation/2/context.json","seeAlso":{"format":"application/xml","@id":"https://noah.nrw/oai?verb=GetRecord&metadataPrefix=mets&identifier=5104800","label":"METS"},"@id":"https://noah.nrw/i3f/v20/5104800/manifest","@type":"sc:Manifest","metadata":[{"value":"Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (p) ppGpp synthase","label":"Titel"},{"value":"Brockmann-Gretza, Olaf","label":"Verfasser"},{"value":"Kalinowski, J\u00f6rn","label":"Verfasser"},{"value":"BMC Genomics, Jg. 7 H. 1, S. 230 ff.","label":"Enthalten in"},{"value":"2006","label":"Erschienen"},{"value":"Englisch","label":"Sprache"},{"value":"Aufsatz in einer Zeitschrift","label":"Dokumenttyp"},{"value":"1471-2164","label":"ISSN"},{"value":"urn:nbn:de:0070-pub-15978141","label":"URN"},{"value":"10.1186/1471-2164-7-230","label":"DOI"}]}