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Mit etwa 71% war sie Leitsymptom bei den Vitamin B6-Respondern, mit 50% war dies bei den non-responsiven Patienten seltener der Fall. In vorangehenden Studien zeigte sich ebenfalls als initiales Leitsymptom in den meisten F\u00e4llen eine Linsenluxation selbst oder eine der Linsenluxation h\u00e4ufig vorangehende hochgradige Myopie (Mudd et al. 1985). Daher "},{"canvases":["https://noah.nrw/i3f/v20/4293484/canvas/4734063"],"@id":"https://noah.nrw/i3f/v20/4293484/range/4734062","@type":"sc:Range","label":"Eine Einschr\u00e4nkung der Aussagekraft des Vergleiches von Symptom-Pr\u00e4valenzen innerhalb verschiedener Studienkollektive ergibt sich durch die vernachl\u00e4ssigte unterschiedliche Altersverteilung innerhalb der Kollektive, da sich die Symptome in typischen Altersklassen bevorzugt entwickeln. Unterschiedliche Diagnosekriterien und Untersuchungsverfahren bez\u00fcglich der klinischen Symptome k\u00f6nnen ebenfalls Einfluss auf das Ergebnis nehmen. 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