{"viewingHint":"paged","service":[{"profile":"http://iiif.io/api/search/1/search","@context":"http://iiif.io/api/search/1/context.json","@id":"https://noah.nrw/i3f/manifest/4283119/search","label":"Search within this manifest"}],"license":"https://creativecommons.org/licenses/by/4.0/deed.de","structures":[{"ranges":["https://noah.nrw/i3f/v20/4283119/range/4982319","https://noah.nrw/i3f/v20/4283119/range/4982321","https://noah.nrw/i3f/v20/4283119/range/4982328","https://noah.nrw/i3f/v20/4283119/range/4982331","https://noah.nrw/i3f/v20/4283119/range/4982332","https://noah.nrw/i3f/v20/4283119/range/4982333","https://noah.nrw/i3f/v20/4283119/range/4982335","https://noah.nrw/i3f/v20/4283119/range/4982337","https://noah.nrw/i3f/v20/4283119/range/4982341","https://noah.nrw/i3f/v20/4283119/range/4982346","https://noah.nrw/i3f/v20/4283119/range/4982349","https://noah.nrw/i3f/v20/4283119/range/4982352"],"viewingHint":"top","@id":"https://noah.nrw/i3f/v20/4283119/range/4283119","@type":"sc:Range","label":"Table of Contents"},{"canvases":["https://noah.nrw/i3f/v20/4283119/canvas/4982320"],"@id":"https://noah.nrw/i3f/v20/4283119/range/4982319","@type":"sc:Range","label":"Hippocampal neurons from Sema3a knockout mice form multiple axons. "},{"canvases":["https://noah.nrw/i3f/v20/4283119/canvas/4982322","https://noah.nrw/i3f/v20/4283119/canvas/4982327"],"ranges":["https://noah.nrw/i3f/v20/4283119/range/4982323","https://noah.nrw/i3f/v20/4283119/range/4982324","https://noah.nrw/i3f/v20/4283119/range/4982325","https://noah.nrw/i3f/v20/4283119/range/4982326"],"@id":"https://noah.nrw/i3f/v20/4283119/range/4982321","@type":"sc:Range","label":"Figure 1 Hippocampal neurons from Sema3a\u2212/\u2212 embryos extend supernumerary axons in culture."},{"canvases":["https://noah.nrw/i3f/v20/4283119/canvas/4982327"],"@id":"https://noah.nrw/i3f/v20/4283119/range/4982326","@type":"sc:Range","label":"Plexin-A1 acts upstream of Rap1 GTPases during neuronal polarization. "},{"canvases":["https://noah.nrw/i3f/v20/4283119/canvas/4982330"],"ranges":["https://noah.nrw/i3f/v20/4283119/range/4982329"],"@id":"https://noah.nrw/i3f/v20/4283119/range/4982328","@type":"sc:Range","label":"Figure 2 Knockdown of Sema3A induces the formation of supernumerary axons."},{"canvases":["https://noah.nrw/i3f/v20/4283119/canvas/4982330"],"@id":"https://noah.nrw/i3f/v20/4283119/range/4982329","@type":"sc:Range","label":"Rap1B acts downstream of Sema3A in hippocampal neurons. "},{"canvases":["https://noah.nrw/i3f/v20/4283119/canvas/4982334"],"@id":"https://noah.nrw/i3f/v20/4283119/range/4982333","@type":"sc:Range","label":"Figure 4 Knockdown of Plexin-A1 induces the formation of supernumerary axons."},{"canvases":["https://noah.nrw/i3f/v20/4283119/canvas/4982336"],"@id":"https://noah.nrw/i3f/v20/4283119/range/4982335","@type":"sc:Range","label":"Figure 5 Knockdown of Rap1B counteracts the induction of supernumerary axons by dominant-negative Plexin-A1."},{"canvases":["https://noah.nrw/i3f/v20/4283119/canvas/4982339"],"ranges":["https://noah.nrw/i3f/v20/4283119/range/4982338","https://noah.nrw/i3f/v20/4283119/range/4982340"],"@id":"https://noah.nrw/i3f/v20/4283119/range/4982337","@type":"sc:Range","label":"Materials and Methods\r"},{"canvases":["https://noah.nrw/i3f/v20/4283119/canvas/4982339"],"@id":"https://noah.nrw/i3f/v20/4283119/range/4982338","@type":"sc:Range","label":"Sema3a knockout mice. "},{"canvases":["https://noah.nrw/i3f/v20/4283119/canvas/4982343"],"ranges":["https://noah.nrw/i3f/v20/4283119/range/4982342","https://noah.nrw/i3f/v20/4283119/range/4982344","https://noah.nrw/i3f/v20/4283119/range/4982345"],"@id":"https://noah.nrw/i3f/v20/4283119/range/4982341","@type":"sc:Range","label":"Figure 6 Active Rap1B recues the suppression of axon formation by constitutively active Plexin-A1."},{"canvases":["https://noah.nrw/i3f/v20/4283119/canvas/4982343"],"@id":"https://noah.nrw/i3f/v20/4283119/range/4982342","@type":"sc:Range","label":"Immunofluorescence staining. "},{"canvases":["https://noah.nrw/i3f/v20/4283119/canvas/4982348"],"ranges":["https://noah.nrw/i3f/v20/4283119/range/4982347"],"@id":"https://noah.nrw/i3f/v20/4283119/range/4982346","@type":"sc:Range","label":"Figure 7 Rap1B is required for the induction of supernumerary axons by the knockdown of Plexin-A1 in hippocampal neurons."},{"canvases":["https://noah.nrw/i3f/v20/4283119/canvas/4982348"],"@id":"https://noah.nrw/i3f/v20/4283119/range/4982347","@type":"sc:Range","label":"Transfection of HEK 293T cells and Western blot. "},{"canvases":["https://noah.nrw/i3f/v20/4283119/canvas/4982351"],"ranges":["https://noah.nrw/i3f/v20/4283119/range/4982350"],"@id":"https://noah.nrw/i3f/v20/4283119/range/4982349","@type":"sc:Range","label":"Figure 8 Rap1B acts downstream of Sema3A in hippocampal neurons."},{"canvases":["https://noah.nrw/i3f/v20/4283119/canvas/4982351"],"@id":"https://noah.nrw/i3f/v20/4283119/range/4982350","@type":"sc:Range","label":"Quantification. 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W.","label":"Verfasser"},{"value":"23.10.2018","label":"Erschienen"},{"value":"Finanziert durch den Open-Access-Publikationsfonds 2018 der Deutschen Forschungsgemeinschaft (DFG) und der Westf\u00e4lischen Wilhelms-Universit\u00e4t M\u00fcnster (WWU M\u00fcnster).","label":"Anmerkung"},{"value":"Englisch","label":"Sprache"},{"value":"Scientific Reports 8 (2018) 15647, 1-13","label":"Bibl. Referenz"},{"value":"Aufsatz in einer Zeitschrift","label":"Dokumenttyp"},{"value":"urn:nbn:de:hbz:6-14199406949","label":"URN"},{"value":"10.1038/s41598-018-34092-5","label":"DOI"}],"@id":"https://noah.nrw/i3f/v20/4283119/manifest","@type":"sc:Manifest","seeAlso":{"format":"application/xml","@id":"https://noah.nrw/oai?verb=GetRecord&metadataPrefix=mets&identifier=4283119","label":"METS"}}